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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. Any process that modulates the frequency, rate, extent or accuracy of translational elongation. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of translational elongation
Acc: GO:0045900
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation.
Synonyms:
  • down-regulation of translational elongation
  • downregulation of translational elongation
  • inhibition of translational elongation
  • down regulation of translational elongation
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045900 - negative regulation of translational elongation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle