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Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte differentiation. Any process that stops, prevents or reduces the frequency, rate or extent of epidermal cell differentiation. The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). Any process that modulates the frequency, rate or extent of epidermis development. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features. Any process that stops, prevents or reduces the frequency, rate or extent of epidermis development. Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. Any process that modulates the frequency, rate or extent of epidermal cell differentiation. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of epidermal cell differentiation
Acc: GO:0045605
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of epidermal cell differentiation.
Synonyms:
  • down regulation of epidermal cell differentiation
  • inhibition of epidermal cell differentiation
  • negative regulation of hypodermal cell differentiation
  • down-regulation of epidermal cell differentiation
  • downregulation of epidermal cell differentiation
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045605 - negative regulation of epidermal cell differentiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle