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Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. The process by which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation. Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. Any process that modulates the frequency, rate or extent of T cell differentiation. Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation. Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells. Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte differentiation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of regulatory T cell differentiation
Acc: GO:0045590
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.
Synonyms:
  • inhibition of regulatory T cell differentiation
  • negative regulation of suppressor T cell differentiation
  • downregulation of regulatory T cell differentiation
  • down-regulation of regulatory T cell differentiation
  • negative regulation of regulatory T lymphocyte differentiation
  • negative regulation of suppressor T-cell differentiation
  • down regulation of regulatory T cell differentiation
  • negative regulation of regulatory T-lymphocyte differentiation
  • negative regulation of regulatory T-cell differentiation
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045590 - negative regulation of regulatory T cell differentiation (interactive image map)
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