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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. The chemical reactions and pathways resulting in the formation of interferon-alpha. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. Any process that modulates the frequency, rate, or extent of interferon-alpha production. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha. The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha. The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of interferon-alpha biosynthetic process
Acc: GO:0045355
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.
Synonyms:
  • negative regulation of interferon-alpha anabolism
  • negative regulation of interferon-alpha formation
  • negative regulation of interferon-alpha synthesis
  • downregulation of interferon-alpha biosynthetic process
  • inhibition of interferon-alpha biosynthetic process
  • negative regulation of interferon-alpha biosynthesis
  • down-regulation of interferon-alpha biosynthetic process
  • down regulation of interferon-alpha biosynthetic process
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045355 - negative regulation of interferon-alpha biosynthetic process (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle