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The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. The process of T cell selection that occurs in the thymus. The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. The process by which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: positive thymic T cell selection
Acc: GO:0045059
Aspect: Biological Process
Desc: The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms:
  • positive thymic T-lymphocyte selection
  • positive thymic T lymphocyte selection
  • positive thymic T-cell selection
Proteins in PDR annotated with:
   This term: 20 [Search]
   Term or descendants: 20 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045059 - positive thymic T cell selection (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle