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Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine. Catalysis of the hydrolysis of ester linkages within nucleic acids. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: T/G mismatch-specific endonuclease activity
Acc: GO:0043765
Aspect: Molecular Function
Desc: Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine.
Synonyms:
  • DNA mismatch endonuclease
  • Vsr mismatch endonuclease
  • V.EcoKDcm
  • very short patch repair protein
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043765 - T/G mismatch-specific endonuclease activity (interactive image map)
YRC Informatics Platform - Version 3.0
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