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The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template. The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination. A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA synthesis involved in double-strand break repair via homologous recombination
Acc: GO:0043150
Aspect: Biological Process
Desc: The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination.
Synonyms:
  • DNA synthesis during double-strand break repair via homologous recombination
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043150 - DNA synthesis involved in double-strand break repair via homologous recombination (interactive image map)
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