YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The process whereby a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. The process whereby a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: MAPKKK cascade involved in epidermal growth factor receptor signaling
Acc: GO:0035559
Aspect: Biological Process
Desc: The process whereby a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms:
  • MAPKKK cascade involved in signaling from the EGFR
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035559 - MAPKKK cascade involved in epidermal growth factor receptor signaling (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle