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Any process that modulates the frequency, rate or extent of hippo signaling. The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. Any process that stops, prevents or reduces the frequency, rate or extent of hippo signaling. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. Any process that activates or increases the frequency, rate or extent of hippo signaling. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. The series of molecular events whereby information is sent from one location to another within a cell. The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hippo signaling pathway
Acc: GO:0035329
Aspect: Biological Process
Desc: The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
Synonyms:
  • Salvador-Warts-Hippo signaling pathway
  • SWH pathway
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 18 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035329 - hippo signaling pathway (interactive image map)
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