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The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC). Any process by which RNA molecules inactivate expression of target genes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: miRNA loading onto RISC involved in gene silencing by miRNA
Acc: GO:0035280
Aspect: Biological Process
Desc: The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC).
Synonyms:
  • miRNA-mediated gene silencing, miRNA loading onto RISC
  • gene silencing by miRNA, miRNA loading onto RISC
  • miRISC assembly
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035280 - miRNA loading onto RISC involved in gene silencing by miRNA (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle