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Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. Any process that stops, prevents or reduces the frequency, rate or extent of a defense response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. Any process that affects the rate, extent or location of the melanization defense response during injury or invasion. The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin. The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection. Any process that stops, prevents or reduces the frequency, rate or extent of the innate immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of melanization defense response
Acc: GO:0035009
Aspect: Biological Process
Desc: Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection.
Synonyms:
  • down regulation of melanization defense response
  • downregulation of melanization defense response
  • inhibition of melanization defense response
  • negative regulation of melanization defence response
  • down-regulation of melanization defense response
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035009 - negative regulation of melanization defense response (interactive image map)
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