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The actin nucleation process by which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: Arp2/3 complex-mediated actin nucleation
Acc: GO:0034314
Aspect: Biological Process
Desc: The actin nucleation process by which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
Synonyms:
  • branched actin filament nucleation
  • actin filament branch nucleation
Proteins in PDR annotated with:
   This term: 16 [Search]
   Term or descendants: 17 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0034314 - Arp2/3 complex-mediated actin nucleation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle