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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling pathway. Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling pathway. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of stress-activated MAPK cascade
Acc: GO:0032873
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
Synonyms:
  • negative regulation of stress-activated MAPK signaling pathway
  • negative regulation of stress-activated MAPKKK signalling pathway
  • negative regulation of stress-activated MAPKKK signaling pathway
  • downregulation of stress-activated MAPK cascade
  • negative regulation of stress-activated MAPKKK cascade
  • negative regulation of stress-activated MAPK signalling pathway
  • down-regulation of stress-activated MAPK cascade
  • inhibition of stress-activated MAPK cascade
  • negative regulation of p38 MAPK signalling
  • negative regulation of p38 MAPK signaling
  • down regulation of stress-activated MAPK cascade
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0032873 - negative regulation of stress-activated MAPK cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle