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Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. Interacting selectively with a DNA sequence that controls the expression of a gene. Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: purine-rich negative regulatory element binding
Acc: GO:0032422
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.
Synonyms:
  • PNR element binding
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0032422 - purine-rich negative regulatory element binding (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle