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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication. The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Any process that modulates the frequency, rate or extent of DNA replication.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of DNA replication initiation
Acc: GO:0032297
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.
Synonyms:
  • inhibition of DNA replication initiation
  • down regulation of DNA replication initiation
  • downregulation of DNA replication initiation
  • down-regulation of DNA replication initiation
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 59 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0032297 - negative regulation of DNA replication initiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle