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Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18. Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: very long-chain fatty acid-CoA ligase activity
Acc: GO:0031957
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18.
Synonyms:
  • very-long-chain fatty acid activation
  • very-long-chain fatty acid-CoA ligase activity
  • very-long-chain-fatty-acid-CoA ligase activity
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031957 - very long-chain fatty acid-CoA ligase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle