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The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process by which RNA molecules inactivate expression of target genes. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process by which RNA molecules inactivate expression of target genes. A process by which the targeting of nascent transcripts by the RITS complex mediates chromatin modifications and promotes the degradation of nascent transcripts synthesized in heterochromatic regions. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. Any process by which RNA molecules inactivate expression of target genes. The process by which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: gene silencing by RNA
Acc: GO:0031047
Aspect: Biological Process
Desc: Any process by which RNA molecules inactivate expression of target genes.
Synonyms:
  • RNA-mediated gene silencing
Proteins in PDR annotated with:
   This term: 46 [Search]
   Term or descendants: 257 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031047 - gene silencing by RNA (interactive image map)
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