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The enzymatic addition of a farnesyl moiety to a protein as a posttranslational modification. The enzymatic addition of prenyl moieties to proteins as a posttranslational modification; geranyl, farnesyl, or geranylgeranyl groups may be added. The covalent attachment of a farnesyl moiety to a protein amino acid. The covalent attachment of a prenyl moiety to a protein amino acid. The posttranslational modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic. The posttranslational modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: protein amino acid farnesylation
Acc: GO:0018347
Aspect: Biological Process
Desc: The covalent attachment of a farnesyl moiety to a protein amino acid.
Synonyms:
  • C-terminal protein farnesylation
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0018347 - protein amino acid farnesylation (interactive image map)

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