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Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine. Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ceramidase activity
Acc: GO:0017040
Aspect: Molecular Function
Desc: Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.
Synonyms:
  • acylsphingosine deacylase activity
  • glycosphingolipid ceramide deacylase
  • N-acylsphingosine amidohydrolase activity
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 48 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0017040 - ceramidase activity (interactive image map)
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