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The process by which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. The process by which a cell becomes committed to become a neural crest cell. The process by which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed. The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. The process whereby a relatively unspecialized cell acquires specialized features of a neural crest cell. The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: neural crest cell fate commitment
Acc: GO:0014034
Aspect: Biological Process
Desc: The process by which a cell becomes committed to become a neural crest cell.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014034 - neural crest cell fate commitment (interactive image map)
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