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Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus. The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell. The process whereby the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast. The process whereby a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whereby a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: neuroblast fate commitment
Acc: GO:0014017
Aspect: Biological Process
Desc: The process whereby the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 45 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014017 - neuroblast fate commitment (interactive image map)
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