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Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Any process that modulates the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of spindle pole body separation
Acc: GO:0010697
Aspect: Biological Process
Desc: Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane.
Synonyms:
  • negative regulation of SPB separation
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0010697 - negative regulation of spindle pole body separation (interactive image map)
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