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Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: NAD(P) transhydrogenase activity
Acc: GO:0008746
Aspect: Molecular Function
Desc: Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.
Synonyms:
  • NAD transhydrogenase
  • NADPH-NAD transhydrogenase
  • nicotinamide adenine dinucleotide (phosphate) transhydrogenase
  • NADH transhydrogenase
  • NADH-NADP-transhydrogenase
  • H+-thase
  • energy-linked transhydrogenase
  • NADPH-NAD oxidoreductase
  • NADPH:NAD+ transhydrogenase
  • pyridine nucleotide transferase
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008746 - NAD(P) transhydrogenase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle