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Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: 4-hydroxy-2-oxoglutarate aldolase activity
Acc: GO:0008700
Aspect: Molecular Function
Desc: Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
Synonyms:
  • 4-hydroxy-2-ketoglutaric aldolase activity
  • hydroxyketoglutarate aldolase activity
  • KHG-aldolase activity
  • 2-keto-4-hydroxyglutarate aldolase activity
  • 2-oxo-4-hydroxyglutaric aldolase activity
  • DL-4-hydroxy-2-ketoglutarate aldolase activity
  • 2-oxo-4-hydroxyglutarate aldolase activity
  • 4-hydroxy-2-oxoglutarate glyoxylate-lyase activity
  • 2-keto-4-hydroxybutyrate aldolase activity
  • hydroxyketoglutaric aldolase activity
  • 4-hydroxy-2-ketoglutarate aldolase activity
  • 2-keto-4-hydroxyglutaric aldolase activity
  • 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008700 - 4-hydroxy-2-oxoglutarate aldolase activity (interactive image map)

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