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Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. The process, arising in non-dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function. The process, arising in dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function. The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: age-dependent general metabolic decline
Acc: GO:0007571
Aspect: Biological Process
Desc: The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis.
Synonyms:
  • age-dependent yeast cell size increase
  • age-dependent decreased translational activity
  • nucleolar size increase
  • age-dependent increased protein content
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 20 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007571 - age-dependent general metabolic decline (interactive image map)
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