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The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Any process leading to the attainment of the full functional capacity of a protein. The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: patched ligand maturation
Acc: GO:0007225
Aspect: Biological Process
Desc: The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
Synonyms:
  • Hedgehog protein processing
  • hh protein processing
  • patched ligand processing
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007225 - patched ligand maturation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle