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Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. Any process that modulates the frequency, rate or extent of protein kinase activity. Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands. Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity. Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. Any process that modulates the frequency, rate or extent of EGF receptor activity. Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity. Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of epidermal growth factor receptor activity
Acc: GO:0007175
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
Synonyms:
  • downregulation of epidermal growth factor receptor activity
  • down regulation of epidermal growth factor receptor activity
  • down-regulation of epidermal growth factor receptor activity
  • inhibition of epidermal growth factor receptor activity
  • negative regulation of EGF receptor activity
  • negative regulation of EGFR activity
  • GO:0007177
  • EGF receptor downregulation
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007175 - negative regulation of epidermal growth factor receptor activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle