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A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. Any process that modulates the rate or extent of progress through the mitotic cell cycle. A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. Any cell cycle checkpoint that blocks entry into M phase. A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage. The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: mitotic cell cycle G2/M transition DNA damage checkpoint
Acc: GO:0007095
Aspect: Biological Process
Desc: A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA.
Synonyms:
  • mitotic G2 checkpoint
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 10 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007095 - mitotic cell cycle G2/M transition DNA damage checkpoint (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle