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Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process by which the cell cycle is halted during one of the normal phases. Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. A cascade of processes induced by the detection of DNA damage within a cell. Any cell cycle checkpoint that blocks entry into S phase. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M). A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. A G1/S transition checkpoint that blocks entry into S phase in response to DNA damage. Any process that increases the rate, frequency, or extent of cell cycle arrest, the process by which the cell cycle is halted during one of the normal phases. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Acc: GO:0006977
Aspect: Biological Process
Desc: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
Synonyms:
  • positive regulation of cell cycle arrest by p53-mediated DNA damage response
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (interactive image map)

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