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Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion. The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure. The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions. The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of cell adhesion involved in substrate-bound cell migration
Acc: GO:0006933
Aspect: Biological Process
Desc: The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction.
Synonyms:
  • substrate-bound cell migration, cell release from substrate
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006933 - negative regulation of cell adhesion involved in substrate-bound cell migration (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle