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The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. The removal of the signal peptide from a nascent protein during cotranslational membrane targeting. The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
Acc: GO:0006618
Aspect: Biological Process
Desc: The removal of the signal peptide from a nascent protein during cotranslational membrane targeting.
Synonyms:
  • signal sequence processing during SRP-dependent cotranslational protein targeting to membrane
  • SRP-dependent cotranslational protein-membrane targeting, signal sequence processing
  • SRP-dependent cotranslational membrane targeting, signal sequence processing
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006618 - SRP-dependent cotranslational protein targeting to membrane, signal sequence processing (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle