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The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, GnRH causes the release of follicle-stimulating hormone and luteinizing hormone by the anterior pituitary.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: gonadotropin hormone-releasing hormone activity
Acc: GO:0005183
Aspect: Molecular Function
Desc: The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, GnRH causes the release of follicle-stimulating hormone and luteinizing hormone by the anterior pituitary.
Synonyms:
  • LHRH activity
  • luteinizing hormone/follicle-stimulating hormone releasing factor activity
  • luteinizing hormone-releasing factor activity
  • LH/FSH-RF
  • GnRH activity
  • luteinizing hormone-releasing hormone activity
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005183 - gonadotropin hormone-releasing hormone activity (interactive image map)
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