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Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: thyroxine 5'-deiodinase activity
Acc: GO:0004800
Aspect: Molecular Function
Desc: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.
Synonyms:
  • acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)
  • diiodothyronine 5'-deiodinase activity
  • type II iodothyronine deiodinase activity
  • iodothyronine 5'-deiodinase activity
  • thyroxine 5' deiodinase activity
  • thyroxine deiodinase activity
  • type I iodothyronine deiodinase activity
  • L-thyroxine iodohydrolase (reducing) activity
  • iodothyronine outer ring monodeiodinase activity
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004800 - thyroxine 5'-deiodinase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle