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Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate. Catalysis of the hydrolysis of a glycerophospholipid. Catalysis of the hydrolysis of a lipid or phospholipid.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: sphingomyelin phosphodiesterase activity
Acc: GO:0004767
Aspect: Molecular Function
Desc: Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
Synonyms:
  • neutral sphingomyelinase activity
  • GO:0030231
  • sphingomyelin cholinephosphohydrolase activity
  • acid sphingomyelin phosphodiesterase
  • GO:0030230
  • neutral sphingomyelin phosphodiesterase
  • acid sphingomyelinase activity
  • sphingomyelinase activity
Proteins in PDR annotated with:
   This term: 34 [Search]
   Term or descendants: 34 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004767 - sphingomyelin phosphodiesterase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle