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Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: peptidylamidoglycolate lyase activity
Acc: GO:0004598
Aspect: Molecular Function
Desc: Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.
Synonyms:
  • peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)
  • HGAD
  • peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity
  • PGL
  • peptidylamidoglycolate peptidylamide-lyase activity
  • alpha-hydroxyglycine amidating dealkylase activity
  • PAL
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004598 - peptidylamidoglycolate lyase activity (interactive image map)
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