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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: peptidylglycine monooxygenase activity
Acc: GO:0004504
Aspect: Molecular Function
Desc: Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.
Synonyms:
  • peptidyl alpha-amidating enzyme activity
  • peptidylglycine alpha-hydroxylase activity
  • peptide-alpha-amide synthetase activity
  • PAM activity
  • PAM-A
  • PAM-B
  • peptidylglycine 2-hydroxylase activity
  • peptidylglycine alpha-amidating monooxygenase activity
  • synthase, peptide alpha-amide
  • peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
  • peptide alpha-amidating enzyme
  • peptide alpha-amide synthase activity
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004504 - peptidylglycine monooxygenase activity (interactive image map)
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