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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: dopamine beta-monooxygenase activity
Acc: GO:0004500
Aspect: Molecular Function
Desc: Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O.
Synonyms:
  • dopamine beta-hydroxylase activity
  • dopamine hydroxylase activity
  • dopamine beta-oxidase activity
  • 4-(2-aminoethyl)pyrocatechol beta-oxidase activity
  • 3,4-dihydroxyphenethylamine beta-oxidase activity
  • dopamine-B-hydroxylase activity
  • (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity
  • dopamine b-hydroxylase activity
  • MDBH (membrane-associated dopamine beta-monooxygenase)
  • 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  • oxygenase, dopamine beta-mono-
  • phenylamine beta-hydroxylase activity
  • dopa beta-hydroxylase activity
  • SDBH (soluble dopamine beta-monooxygenase)
Proteins in PDR annotated with:
   This term: 39 [Search]
   Term or descendants: 39 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004500 - dopamine beta-monooxygenase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle