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Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: malate dehydrogenase (decarboxylating) activity
Acc: GO:0004471
Aspect: Molecular Function
Desc: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate.
Synonyms:
  • NAD-specific malic enzyme
  • (S)-malate:NAD+ oxidoreductase (decarboxylating)
  • 'malic' enzyme
  • NAD-malic enzyme activity
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004471 - malate dehydrogenase (decarboxylating) activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle