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Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA. Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: homocitrate synthase activity
Acc: GO:0004410
Aspect: Molecular Function
Desc: Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA.
Synonyms:
  • homocitrate synthetase activity
  • 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity
  • 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
  • acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
  • acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004410 - homocitrate synthase activity (interactive image map)

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