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Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: NAD(P)+ transhydrogenase (B-specific) activity
Acc: GO:0003957
Aspect: Molecular Function
Desc: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
Synonyms:
  • NAD(P) transhydrogenase (B-specific) activity
  • NADPH:NAD+ oxidoreductase (B-specific)
  • NAD transhydrogenase
  • NADPH-NAD transhydrogenase
  • NADH-NADP-transhydrogenase
  • H+-thase
  • NADPH-NAD oxidoreductase
  • NADPH:NAD+ transhydrogenase
  • pyridine nucleotide transferase
  • nicotinamide nucleotide transhydrogenase activity
  • nicotinamide adenine dinucleotide (phosphate) transhydrogenase
  • NADH transhydrogenase
  • non-energy-linked transhydrogenase activity
  • pyridine nucleotide transhydrogenase activity
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003957 - NAD(P)+ transhydrogenase (B-specific) activity (interactive image map)

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