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Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R. Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Acc: GO:0003828
Aspect: Molecular Function
Desc: Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R.
Synonyms:
  • CMP-NeuAc:LM1(alpha2-8) sialyltranferase activity
  • ganglioside GD3 synthase activity
  • alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
  • GD3 synthase activity
  • cytidine monophosphoacetylneuraminate-ganglioside GM3
  • CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity
  • ganglioside GD3 synthetase sialyltransferase activity
  • SAT-2
  • alpha-2,8-sialyltransferase activity
Proteins in PDR annotated with:
   This term: 9 [Search]
   Term or descendants: 9 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003828 - alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity (interactive image map)
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