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The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages. The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. The process by which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: myeloid leukocyte differentiation
Acc: GO:0002573
Aspect: Biological Process
Desc: The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
Synonyms:
  • myeloid leucocyte differentiation
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 151 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002573 - myeloid leukocyte differentiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle