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Tolerance induction to nonself antigens in the central lymphoid organs. Tolerance induction of B cells in the bone marrow. Tolerance induction of T cells in the thymus. Any process that activates or increases the frequency, rate, or extent of central tolerance induction. Tolerance induction in the central lymphoid organs directed at self antigens. Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction. Tolerance induction in the central lymphoid organs: the thymus and bone marrow. Any process that modulates the frequency, rate, or extent of central tolerance induction. The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: central tolerance induction
Acc: GO:0002508
Aspect: Biological Process
Desc: Tolerance induction in the central lymphoid organs: the thymus and bone marrow.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002508 - central tolerance induction (interactive image map)
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