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An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other. The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
Acc: GO:0002415
Aspect: Biological Process
Desc: The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
Synonyms:
  • immunoglobulin transcytosis mediated by pIgR
  • antibody transcytosis mediated by pIgR
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002415 - immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor (interactive image map)
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