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The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival. An immune response mediated by immunoglobulins, whether cell-bound or in solution. Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of an immune response. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. The process by which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen. Any B cell selection process that occurs in the periphery. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: B cell affinity maturation
Acc: GO:0002344
Aspect: Biological Process
Desc: The process by which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:
  • B-lymphocyte affinity maturation
  • B-cell affinity maturation
  • B lymphocyte affinity maturation
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002344 - B cell affinity maturation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle