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The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. Any process involved in the carrying out of an immune response by a lymphocyte. An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. A process that directly activates any of the steps required for cell death by apoptosis. A process which directly activates any of the steps required for programmed cell death. The directed killing of a target cell by a leukocyte. Any process of the immune system that occurs as part of an immune response. Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity. Any process involved in the carrying out of an immune response by a T cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: T cell mediated cytotoxicity
Acc: GO:0001913
Aspect: Biological Process
Desc: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Synonyms:
  • T cell mediated cytolysis
  • T-lymphocyte mediated cytotoxicity
  • T cell mediated cell killing
  • T-cell mediated apoptosis
  • T lymphocyte mediated cytotoxicity
  • T-cell mediated cell killing
  • T cell mediated apoptosis
  • T-cell mediated cell death
  • T cell mediated cell death
  • T-cell mediated cytotoxicity
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 61 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001913 - T cell mediated cytotoxicity (interactive image map)
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