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The directed killing of a target cell by a neutrophil. The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. The directed killing of a target cell by a leukocyte. Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. Any process of the immune system that occurs as part of an immune response. Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity. Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity. Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: leukocyte mediated cytotoxicity
Acc: GO:0001909
Aspect: Biological Process
Desc: The directed killing of a target cell by a leukocyte.
Synonyms:
  • immune cell mediated cell killing
  • leucocyte mediated cytotoxicity
  • immune cell mediated cytotoxicity
  • immune cell mediated cell death
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 119 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001909 - leukocyte mediated cytotoxicity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle