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A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages. Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. Any process that modulates the frequency, rate or extent of natural killer cell differentiation. The process whereby a relatively unspecialized cell acquires the specialized features of a natural killer cell. Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation. The process whereby a nave natural killer cell acquires the specialized features of an effector natural killer T cell during an immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: natural killer cell differentiation
Acc: GO:0001779
Aspect: Biological Process
Desc: The process whereby a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Synonyms:
  • NK cell differentiation
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001779 - natural killer cell differentiation (interactive image map)

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