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Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age. Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. The process by which changes in chromatin structure contributing to replicative cell aging occurs. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: extrachromosomal circular DNA accumulation involved in replicative cell aging
Acc: GO:0001307
Aspect: Biological Process
Desc: Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.
Synonyms:
  • extrachromosomal circular DNA accumulation during replicative cell ageing
  • extrachromosomal circular DNA accumulation during replicative cell aging
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001307 - extrachromosomal circular DNA accumulation involved in replicative cell aging (interactive image map)
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