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Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing. Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: alternative nuclear mRNA splicing, via spliceosome
Acc: GO:0000380
Aspect: Biological Process
Desc: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
Synonyms:
  • splice site selection
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 133 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000380 - alternative nuclear mRNA splicing, via spliceosome (interactive image map)
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Created and Maintained by: Michael Riffle